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Ten selected Publications

• Eberlein J, Groos N, Shrestha Duwal N, Sugden WW, North TE, Helker CSM. (2026)
  Apelin signaling acts as a molecular switch between endothelial and hematopoietic stem cell fates.
  EMBO Rep. Feb;27(4):899-924. 
  doi: 10.1038/s44319-025-00656-6. Epub 2025 Dec 16.PMID: 41402492 Free
   
• Herdt L, Baumeister S, Ravindra J, Eberlein J, Helker CSM. (2025)
  Apelin as a CNS-specific pathway for fenestrated capillary formation in the choroid plexus.
  Nat Commun. Aug 19;16(1):7729. 
  doi: 10.1038/s41467-025-63003-2.PMID: 40830138
   
• Herdt L, Schihada H, Kurz M, Ernst S, Eberlein J, Kolb P, Krasel C, Bünemann M, Helker CSM. (2025)
  In vivo measurement of an Apelin gradient with a genetically encoded APLNR conformation biosensor.
  Nat Commun. Jul 21;16(1):6682. 
  doi: 10.1038/s41467-025-61781-3.PMID: 40691309
   
• Malchow J., Eberlein J., Li W., Hogan, B.M., Okuda, K.S.,  Helker, C.S.M. (2024). 
  Neural progenitor-derived Apelin controls tip cell behavior and vascular patterning. 
  Science Adv. 10(27):eadk1174, 
  doi: 10.1126/sciadv.adk1174. PMID: 38968355
   
• Rinné S., Kiper A.K., Jacob R., Ortiz-Bonnin B., Schindler R.F.R., Fischer S., Komadowski M., De Martino E., Schäfer M.K.H., Cornelius T., Fabritz L., Helker, C.S.M., Brand T., Decher N. (2024). 
  Popeye domain containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5. 
  iScience 27(5):109696, 
  doi: 10.1016/j.isci.2024.109696. PMID:38689644
   
• Nakajima H., Ishikawa H., Yamamoto T., Chiba A., Fukui H., Sako K., Fukumoto M., Mattonet K., Kwon H.B., Hui S.P., Dobreva G.D., Kikuchi K., Helker, C.S.M., Stainier D.Y.R., Mochizuki N. (2023). 
  Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. 
  Developmental Cell. 58(3):224-238.e7. 
  doi: 10.1016/j.devcel.2022.12.013. PMID: 36693371
   
• Jialing Qi, Rittershaus A., Priya R., Mansingh S., Stainier D.Y.R.*, Helker, C.S.M * (2022). 
  Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish. 
  Elife. 11:e73231. 
  doi: 10.7554/eLife.73231 PMID: 35225788. (*Shared-last Corresponding authors)
   
• Boezio, G.L.M., Bensimon-Brito, A., Piesker, J., Guenther, S., Helker, C.S.M.*, Stainier, D.Y.R.* (2020). 
  Endothelial TGF-β signaling instructs smooth muscle development in the cardiac outflow tract, 
  Elife. 9:e57603. 
  doi: 10.7554/eLife.57603. PMID: 32990594. (*Shared-last Corresponding authors)
   
• Helker, C.S.M.*, Eberlein, J., Wilhelm, K., Sugino, T., Malchow, J., Schuermann, A., Baumeister, S., Kwon, H.B., Maischein, H.M., Potente, M., Herzog, W., and Stainier, D.Y.R.* (2020). 
  Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state, 
  Elife. 9:e55589. 
  doi: 10.7554/eLife.55589. PMID: 32955436. (*Corresponding authors)
   
• Helker, C.S.M.*, Mullapudi ST, Mueller LM, Preussner J, Tunaru S, Skog O, Kwon HB, Kreuder F, Lancman JJ, Bonnavion R, Dong PDS, Looso M, Offermanns S, Korsgren O, Spagnoli FM, Stainier DYR* (2019). 
  A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development. 
  Development. 146(14):dev172569. 
  doi: 10.1242/dev.172569. PMID:31142539. (*Corresponding authors)